Localized motif discovery in gene regulatory sequences
نویسندگان
چکیده
منابع مشابه
For the paper “ Localized Motif Discovery in Gene Regulatory Sequences ”
LocalMotif uses a combination of three different scoring functions which individually describe three different characteristics of a motif. The relative entropy score (RES) measures the degree of surprise in the motif nucleotide pattern with respect to the background distribution of nucleotides. The over-representation score (ORS) measures the overabundance of the number of instances of the moti...
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The purpose of motif discovery as discussed here is to find binding sites of DNA binding regulators. We assume that the binding sites are short segments of DNA, not necessarily contiguous, to which a specific (family of) transcription factors can bind. While such sites may appear in genic as well as intergenic regions, we focus here on finding binding sites only in the promoter region of each ...
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Motif discovery for the identification of functional regulatory elements underlying gene expression is a challenging problem. Sequence inspection often leads to discovery of novel motifs (including transcription factor sites) with previously uncharacterized function in gene expression. Coupled with the complexity underlying tissue-specific gene expression, there are several motifs that are puta...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2010
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btq106